Severe acute pancreatitis (SAP) is prone to develop acute lung injury (ALI), leading to early death, but there is a lack of early warning methods in clinical practice. To identify risk factors, this study first retrospectively enrolled 158 SAP patients, then systematically collected their clinical data, screened independent predictive indicators through univariate and multivariate analyses, and finally constructed a risk prediction model. The APACHE II score, hypocalcemia, and C-reactive protein were shown to be separate ALI risk factors, and the predictive power of the model was significant (AUC=0.89). Research has shown that the risk assessment system based on conventional indicators can identify high-risk patients early and provide effective basis for precise clinical intervention.

Jing Zhou, Xiaofang Zeng, Tao Zeng. The Risk Factors of Acute Lung Injury in Acute Stage in Patients with Severe Acutepancreatitis. International Journal of Health and Pharmaceutical Medicine (2022), Vol. 3, Issue 1: 96-104. https://doi.org/10.38007/IJHPM.2022.030109.

[1] Hu Q, Yao J, Wu X, et al. Emodin attenuates severe acute pancreatitis-associated acute lung injury by suppressing pancreatic exosome-mediated alveolar macrophage activation[J]. Acta pharmaceutica Sinica B, 2022, 12(10): 3986-4003.

[2] Mederos M A, Reber H A, Girgis M D. Acute pancreatitis: a review[J]. Jama, 2021, 325(4): 382-390.

[3] Szatmary P, Grammatikopoulos T, Cai W, et al. Acute pancreatitis: diagnosis and treatment[J]. Drugs, 2022, 82(12): 1251-1276.

[4] Lee D W, Cho C M. Predicting severity of acute pancreatitis[J]. Medicina, 2022, 58(6): 787-791.

[5] Dang W, Tao Y, Xu X, et al. The role of lung macrophages in acute respiratory distress syndrome[J]. Inflammation Research, 2022, 71(12): 1417-1432.

[6] Long M E, Mallampalli R K, Horowitz J C. Pathogenesis of pneumonia and acute lung injury[J]. Clinical Science, 2022, 136(10): 747-769.

[7] Fan R, Sui J, Dong X, et al. Wedelolactone alleviates acute pancreatitis and associated lung injury via GPX4 mediated suppression of pyroptosis and ferroptosis[J]. Free Radical Biology and Medicine, 2021, 173(1): 29-40.

[8] Feng Minchao, Luo Fang, Tang Xiping, et al. Therapeutic effect and mechanism of Qingjie Huagong prescription on acute lung injury in rats with severe acute pancreatitis model [J]. Chinese Pharmacological Bulletin, 2024, 40(5):975-983.

[9] Zhao Yonghong, Chen Airong, Hu Mengru, et al. Clinical characteristics and risk factors of acute pancreatitis with metabolic syndrome [J]. Modern Digestion and Interventional Diagnosis and Treatment, 2022, 29(6):664-669.

[10] Zhang Weiwei, Huang Zhenfei, Zhang Min, et al. Risk factors for acute respiratory distress syndrome in patients with severe acute pancreatitis [J]. Contemporary Medicine, 2022, 30(24):140-144.

[11] Zhan Y Q, Ling Y H, Deng Q, et al. HMGB1-mediated neutrophil extracellular trap formation exacerbates intestinal ischemia/reperfusion-induced acute lung injury[J]. The Journal of Immunology, 2022, 208(4): 968-978.

[12] de-Madaria E, Buxbaum J L, Maisonneuve P, et al. Aggressive or moderate fluid resuscitation in acute pancreatitis[J]. New England Journal of Medicine, 2022, 387(11): 989-1000.